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The Nanonics Hydra - The Next Evolution in BioAFM

Awarded Microscopy Today's 2010 Innovation Award

dual_side_view_copy2_320The HydraTM is a new revolution in the BioAFM market that allows integration with any upright or inverted microscope. The Hydra'sTM open design can be integrated into any microscope (unlike other BioAFMs which are limited by geometric or optical obstruction), including advanced concepts in optical microscopy such as 4pi configurations and many non-linear optical protocols. 

The HydraTM incorporates tuning fork feedback mechanism, which provides UltraSensitive Liquid CellTM operation for new sensitivities in AC force spectroscopy. Its Tuning Fork Liquid CellTM also permits Nanonics to offer MultiProbe Atomic Force Microscopy to the BioAFM researcher allowing for new directions in BioAFM imaging and nano-manipulation.

The HydraTM includes a NanoToolKitTM of glass-based probes including transparent AFM probes and nanopipette probes for conductance and futuristic structurally correlated patch clamp applications.  Ideal for all modes of optical microscopy including standard fluorescence techniques – confocal, TIRF, FRET and DIC – The HydraTM can also provide advanced chemical imaging – such as NSOM and AFM Raman combinations with Tip Enhanced Raman Scattering (TERS) – without introducing any constraints to the microscope or the microRaman platform used.

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A  New Class of BioSPM 
  • The only BioSPM that permits independent and simultaneous multiprobe operation.

  •  The only BioSPM that can integrate with any optical microscope.
    • Upright
    • Inverted
    • Dual 4pi Configurations
    • Raman/Confocal/DIC/NSOM  
  • The only BioSPM that permits critically acclaimed tuning fork feedback in liquid.
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  • Liquid cell without optical and mechanical constraints or interference.

  • A NanoTool KitTM of multifunctional probes for multiprobe operation.
    • Conductance & Patch Clamping
    • Apertured & Apertureless NSOM
    • Single Gold Ball Tipped Probes
    • BioMolecular Nanolithography

  • All probes non-optically interfering 
             
Reach New Heights of Spectral   Bio-Imaging

Spectral Packages

Confocal fluorescence imaging and lifetime confocal Raman

Confocal Raman

Tip Enhanced Raman Scattering

Total internal reflectance fluorescence

Modularity

Connect to any MicroRaman or monochromator.

Add individually controlled multiple SPM probes one at a time.

Add NSOM fluorescence correlation spectroscopy.

Add force controlled cell penetration & AttoLiter injection

The Flexibility of The Nanonics HydraTM Permits New Directions in SPM Imaging   

Study on line with optics & SPM samples on non-transparent substrates.

Image optically and with SPM highly scattering samples such as textiles, fibers, paper, paints and capsules.

Single molecule studies on gold or other opaque substrates

Biosensors

Optically active materials and compounds 

The Nanonics HydraTM

A Ground-Breaking Advance in AFM Bio-Imaging in Liquids

  • Multi Probe SPM Operation
    • Up to 4 SPM probes
    • Multifunctional probes for manipulation and imaging

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  • Tuning Fork Feedback
    • Ultra soft contact high Q-factors
    • Improved imaging quality
    • Optically free feedback ideal for fluorescence
    • Permits ultrasensitive AC dynamic force spectroscopy  
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  • Standard Petri Dish
    • Compatible with all biological sample preparation 
  • Full Optical Transparency
    • Fully integrated with: RAMAN /TERS /NSOM/ Confocal/ TIRF/ DIC/ STED/ Second Harmonic/
      4 Pi  
  • Tip or Sample Scanning with AFM Autofocus for Confocal Imaging
  • Z range of 100 µm Unachievable with any other SPM
  • Environmental Control
    • Humidity/Temperature/Vacuum
    • Retaining full optical transparency

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THE NEXT EVOLUTION IN SCANNING PROBE MICROSCOPY

 

 

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