AFM imaging of Neuroblastoma cells in liquid |
AFM close-up imaging of Neuroblastoma cells in liquid |
3D AFM imaging of Neuroblastoma cells in liquid | 3D AFM close-up imaging of Neuroblastoma cells in liquid |
Nanonics' systems can use any type of probe, but our unique glass probes are perfect for chromosome nanomanipulation and imaging. Glass probes do not only allow for the imaging of soft structures such as this human chromosome but are also ideal, because of their slender and extended shape, for the precise dissection of such structures. |
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2D and 3D AFM images of Collagen Fibrilis imaged with the optically friendly Nanonics' OptoprobeTM. The images shown clearly repeat the structure of 65nm. |
Yeast Cells
Nanometric scale images obtained without moving anything
These three images show the same region of GFP labelled yeast cell in a physiological medium. The images were obtained simultaneously with the MultiView 1000 system integrated with a Nanonics dual microscope.
Only Nanonics' systems can zoom in on living samples from the far-field to NSOM producing images of such high quality. The simultaneous imaging of a sample in both far- and near-fields, from above and below the sample can be achieved only by virtue of the Nanonics' free optical axis. NSOM imaging of biological samples such as these is possible in the Nanonics liquid cell using optical fiber probes intermittant contact mode. Other NSOM techniques using hollow probes are limited in their ability to image in the intermittant contact mode. |
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Only Nanonics can deliver chemicals or gas onto the sample on line, with no need to remove the tip from the sample. Protein printing is made possible by the Nanonics Chemical Delivery System and Nanopipette
Using any of the Nanonics MultiView systems, chemicals, in liquid or gas form, can be fed into the pipette via a silicon tube. Apart from Protein Printing, applications of this setup include metallic nano-etching and nanolithography: an etchant can be introduced into the sample and scanned across it with nanometer precision using our 3D FlatScanning™ technology. The nanopipette is engaged by the sample using standard contact-mode atomic force microscopy, and our integrated system makes it possible to view the etching simultaneously through any optical microscope.
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Functional Calcium Imaging - An Optical Alternate to Patch Clamping |
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